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  • Dimethylformamide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by A. Bainova / International Programme on Chemical Safety
Sách, tuyển tập Tài liệu điện tử

Dimethylformamide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by A. Bainova / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1991

ISBN : 9241571144

Tùng thư : Environmental health criteria

Chủ đề : 1. Dimethylformamide -- adverse effects toxicity.

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Tóm tắt :

Evaluates risks to human health and the environment posed by the production and use of dimethylformamide, an organic solvent produced in large quantities throughout the world. Dimethylformamide is widely used in the chemical industry as a solvent, an intermediate, and an additive, with the largest quantities used in the production of acrylic fibres and polyurethanes. Dimethylformamide is also used in the production of pharmaceutical products. The opening sections outline the main sources of human and environmental exposure and review studies of the behaviour of dimethylformamide in the environment. Because of its complete solubility in water, dimethylformamide is noted to move readily through soils; accumulation in the food chain is judged unlikely. Concerning effects on organisms in the environment, the limited data available suggest low toxicity for aquatic organisms. The second half of the book reviews findings useful in determining the risks to health posed by exposure of workers and of the general population to dimethylformamide. An extensive review of findings from experimental studies reveals consistent evidence that dimethyl-formamide is a hepatotoxic agent. Both teratogenic and embryotoxic effects have been demonstrated in several species. The final section, which evaluates data from human studies, notes that symptoms associated with cases of acute accidental occupational poisoning are transient and followed by complete recovery. Biochemical signs of liver dysfunction are observed to accompany long-term repeated occupational exposure, but evidence suggesting an increased risk of certain cancers in exposed workers was judged inadequate Summary and evaluation, conclusions and recommendations in French and Spanish124 p.
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https://iris.who.int/handle/10665/37041

 

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